Bioactive Small Molecules
Medchemexpress LLC Katacalcin (TFA) | 99.6% | 2550.62 | 100 MG
Katacalcin TFA (PDN 21 TFA) is a potent plasma calcium-lowering peptide from the calcitonin family. It induces a rapid, short-lived decrease in blood calcium and phosphate by promoting bone incorporation. This peptide, encoded by the calc-1 gene alongside calcitonin and procalcitonin NH2-terminal cleavage peptide, effectively inhibits fMLP-induced chemotaxis and deactivates CD14+ peripheral blood mononuclear cell chemotaxis toward various attractants.
- Potent plasma calcium-lowering peptide
- Belongs to the calcitonin family
- Decreases blood calcium and phosphate levels
- Promotes incorporation into bones
- Inhibits fMLP-induced chemotaxis
- Deactivates CD14+ peripheral blood mononuclear cell chemotaxis
- Regulates CD14+ PBMC migration via protein kinase A-dependent cAMP pathways
Medchemexpress LLC ATP synthase inhibitor 2 | 2814540-76-4 | C21H22N2O3S | 5 MG
This product is an ATP synthase inhibitor, specifically targeting *Pseudomonas aeruginosa*. It demonstrates complete inhibition of ATP synthesis activity in this bacterium at a concentration of 128 μg/mL.
- Inhibits ATP synthase.
- Specifically targets *Pseudomonas aeruginosa*.
- Achieves complete inhibition of ATP synthesis at 128 μg/mL.
- Available in solid form, white to off-white in color.
- Has high purity.
TARGETMOL CHEMICALS INC SIRT5 INHIBITOR 1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50 0.11 uM). sIRT5 inhibitor 1 is associated with ageing-related diseases. purity: 98%
TARGETMOL CHEMICALS INC QUINACAINOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Quinacainol (RP 54272) is a new antiarrhythmic compound with class I antiarrhythmic effects in rats. purity: 99%
Cayman Chemical ANTIBODY RN-486 10mg
A selective BTK inhibitor (Kds = 0.31 nM; IC50 = 4 nM); produces anti-inflammatory and bone-protective effects in mouse collagen-induced arthritis and rat adjuvant-induced arthritis models
Cayman Chemical ANTIBODY Compound E 1mg
A potent, cell-permeable, and selective inhibitor of γ-secretase, blocking the cleavage of both APP and Notch CTFs with IC50 values of ~0.3 nM; induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by γ-secretase
Medchemexpress LLC m7GpppAmpG ammonium | 62858-30-4 | 99.5% | C32H43N15O24P4.xNH3 | 20 UL
m7GpppAmpG ammonium is a trinucleotide 5′ end cap analog that binds to eIF4E and caps RNA. It enhances mRNA stability and translation efficiency, making it valuable for mRNA therapeutic research.
- Trinucleotide 5′ end cap analog
- Binds to eIF4E with a KD value of 45.6 nM
- Caps RNA with 90% efficiency
- Enhances mRNA stability
- Enhances translation efficiency
- Used in mRNA therapeutic research
Medchemexpress LLC Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) protein, rat, His-tagged | 1 MG
Recombinant rat ACAT2 (acyl-coenzyme A:cholesterol acyltransferase 2) is supplied lyophilized with a polyhistidine tag for research applications. Expressed in E. coli, the protein has an approximate molecular weight of 43.3 kDa and is provided with manufacturer handling and storage recommendations, including sequence information and reconstitution guidance.
- Recombinant rat protein with His tag for affinity purification.
- Expressed in E. coli to support common expression workflows.
- Approximately 43.3 kDa molecular weight.
- Lyophilized from PBS, pH 7.4 for stability and transport.
- Storage and reconstitution guidance provided to preserve activity.
- Carrier protein recommended for long-term storage after reconstitution.
Abcam NVP-BEZ235, PI3K and mTOR inhibitor, 5MG
MW 469.5 Da, Purity >98%. Potent, ATP-competitive Phosphatidylinositol 3-kinase (PI3K) inhibitor (IC₅₀ = 4, 5, 7 and 75 nM for PI3Kα, -γ, -δ, and -β respectively) and mTOR inhibitor. Able to directly induce G₁ arrest and inhibit angiogenesis in vitro and potentiate the efficacy of other anticancer agents in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC DO34 analog | 2098969-71-0 | 98.4% | 531.53 g/mol | C26H28F3N5O4 | 1 ML
DO34 analog is a triazole-based diacylglycerol lipase (DAGLα) inhibitor (patent WO2017096315, compound 100) intended for biochemical and cell-based research. It is supplied as a solid and as a ready-to-use 10 mM solution in DMSO, providing high purity and convenient handling for in vitro studies.
- High purity: 98.42%.
- Molecular weight: 531.53 g/mol.
- Chemical formula: C26H28F3N5O4.
- Physical form: Light yellow to yellow solid; also supplied as a solution.
- Solubility: DMSO ≥ 105 mg/mL (≈197.5 mM).
- Storage: Powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
- Available formats: Solids (5 mg, 10 mg, 25 mg, 50 mg, 100 mg) and 10 mM 1 mL solution.
Cayman Chemical ANTIBODY Endothal 50mg
An aquatic plant growth regulator; reduces curly leaf pondweed appearance frequency and dry biomass in lakes at 1 mg/L annually; reduces leaf chlorophyll content in A. thaliana plants and root length in A. thaliana seedlings (IC50s = 1.36 mM and 13.9 µM, respectively) and decreases duckweed growth rate (IC50 = 10 µM); induces production of ethylene in bean leaves at 1 µM; a PP2A inhibitor (IC50 = 19-50 nM); toxic to mice (LD50 = 5-50 mg/kg)
Cayman Chemical ANTIBODY CIpargamIn 10mg
An antimalarial agent; inhibits the Na+-ATPase activity of wild-type or mutant PfATP4 (IC50s = 12.3-13.9 and 21.1-32.5 nM, respectively, in P. falciparum membranes); active against the P. falciparum chloroquine-sensitive strain NF54 and chloroquine-resistant strain K1 (IC50s = 0.5 and 0.6 nM, respectively); reduces parasitemia and increases survival in a mouse model of P. berghei infection at 10, 30, and 100 mg/kg
Cayman Chemical ThIomuscImol 5mg
A GABAA receptor agonist (IC50 = 19 nM) that has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex
Medchemexpress LLC Arecaidine hydrobromide | 6013-57-6 | 5 MG
Arecaidine hydrobromide is a pyridine alkaloid known for its role as a potent GABA uptake inhibitor. It also acts as a substrate for H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and can competitively inhibit L-proline uptake.
- Potent GABA uptake inhibitor
- Substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1)
- Competitively inhibits L-proline uptake
- White to off-white solid appearance
- Intended for research use only
Medchemexpress LLC HY-13404 200mg , Capmatinib CAS:1029712-80-8 Purity:>98%
HY-13404 200mg Capmatinib CAS: 1029712-80-8 Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.